ABSTRACT
OBJECTIVE: To observe the safety and efficacy of rehepatectomy and radiofrequency ablation for patientswith recurrent hepatocellular carcinoma(HCC).METHODS: A consecutive sample of 159 recurrent HCC patients whounderwent rehepatectomy(n=77) or radiofrequency ablation(n=82) from January 2005 to December 2014 were analyzedretrospectively. Propensity score analysis was used. The Kaplan-Meier method was used for survival analysis.RESULTS: Propensity score analysis chose 41 pair patients. Patients in the radiofrequency ablation group were with lower rate ofperioperative mortality and morbidiy,shorter length of hospital stay. When calculate the survival time from the date ofrehepatectomy or radiofrequency ablation,or calculate the survival time from the date of the first hepatectomy,the twoarms showed similar overall survival(P=0.258,0.820). Moreover,overall survival were similar after propensity scoreanalysis(P=0.443,0.917).CONCLUSION: Radiofrequency ablation was safety,associated with shorter length of hospitalstay and similar long-term overall survival with rehepatectomy for recurrent HCC.
ABSTRACT
OBJECTIVE: To perform a meta-analysis to quantitatively assess functional magnetic resonance imaging (MRI) in the diagnosis of locally recurrent prostate cancer. MATERIALS AND METHODS: A comprehensive search of the PubMed, Embase, Cochrane Central Register of Controlled Trials, and Cochrane Database of Systematic Reviews was conducted from January 1, 1995 to December 31, 2016. Diagnostic accuracy was quantitatively pooled for all studies by using hierarchical logistic regression modeling, including bivariate modeling and hierarchical summary receiver operating characteristic (HSROC) curves (AUCs). The Z test was used to determine whether adding functional MRI to T2-weighted imaging (T2WI) results in significantly increased diagnostic sensitivity and specificity. RESULTS: Meta-analysis of 13 studies involving 826 patients who underwent radical prostatectomy showed a pooled sensitivity and specificity of 91%, and the AUC was 0.96. Meta-analysis of 7 studies involving 329 patients who underwent radiotherapy showed a pooled sensitivity of 80% and specificity of 81%, and the AUC was 0.88. Meta-analysis of 11 studies reporting 1669 sextant biopsies from patients who underwent radiotherapy showed a pooled sensitivity of 54% and specificity of 91%, and the AUC was 0.85. Sensitivity after radiotherapy was significantly higher when diffusion-weighted MRI data were combined with T2WI than when only T2WI results were used. This was true when meta-analysis was performed on a per-patient basis (p = 0.027) or per sextant biopsy (p = 0.046). A similar result was found when ¹H-magnetic resonance spectroscopy (¹H-MRS) data were combined with T2WI and sextant biopsy was the unit of analysis (p = 0.036). CONCLUSION: Functional MRI data may not strengthen the ability of T2WI to detect locally recurrent prostate cancer in patients who have undergone radical prostatectomy. By contrast, diffusion-weight MRI and ¹H-MRS data may improve the sensitivity of T2WI for patients who have undergone radiotherapy.